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October 1, 1992Anesthesia & Analgesia

Ondansetron in the Treatment of Postoperative Vomiting

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Why the study?

Does ondansetron prevent postoperative vomiting in patients undergoing general anesthesia for dilatation and curettage compared to droperidol or metoclopramide?

Population

66 patients undergoing general anesthesia for dilatation and curettage.

Comparison

Ondansetron 8 mg single intravenous dose 10… vs Droperidol 1.25 mg single intravenous dose or…

Design

RCT, randomized, double-blind

Follow-up

postoperatively

Authors

EAEli AlonDeutsche Gesellschaft für Internationale ZusammenarbeitSHSabine HimmelseherTechnical University of Munich

Discussion

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Overview

Supports ondansetron as preferred prophylaxis for postoperative vomiting after D&C; confirms superiority over droperidol and metoclopramide in this RCT.

Structured PICO

Does ondansetron prevent postoperative vomiting in patients undergoing general anesthesia for dilatation and curettage compared to droperidol or metoclopramide?

P
Population
66 patients undergoing general anesthesia for dilatation and curettage.
I
Intervention
Ondansetron 8 mg single intravenous dose 10 minutes before induction of anesthesia.
C
Comparator
Droperidol 1.25 mg single intravenous dose or metoclopramide 10 mg single intravenous dose 10 minutes before induction of anesthesia.
O
Outcome
Incidence of postoperative vomitingpatient reported

Preoperative prophylactic administration of ondansetron is superior to droperidol or metoclopramide in preventing postoperative vomiting after general anesthesia for dilatation and curettage.

Cite This Study

Alon et al. (1992) studied this question.

synapsesocial.com/papers/6a76b647d2fa2470761e602bhttps://doi.org/10.1213/00000539-199210000-00017
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ondansetron is effective in decreasing postoperative nausea and vomiting1992 · 27 citations
  2. 2The anti‐emetic efficacy of a combination of ondansetron and droperidol1997 · 27 citations
  3. 3A COMPARATIVE STUDY OF ONDANSETRON VERSUS METOCLOPRAMIDE IN THE PREVENTION OF POST-OPERATIVE VOMITING IN ROUTINE MAJOR GYNECOLOGICAL SURGERY UNDER GENERAL ANESTHESIA1970 · 1 citations
  4. 4Efficacy of prophylactic droperidol, ondansetron or both in the prevention of postoperative nausea and vomiting in major gynaecological surgery. A prospective, randomized, double-blind clinical trial2000 · 17 citations
  5. 5Comparison of Ondansetron Versus Placebo to Prevent Postoperative Nausea and Vomiting in Women Undergoing Ambulatory Gynecologic Surgery1993 · 298 citations