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October 1, 2000European Journal of Anaesthesiology

Efficacy of prophylactic droperidol, ondansetron or both in the prevention of postoperative nausea and vomiting in major gynaecological surgery. A prospective, randomized, double-blind clinical trial

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Why the study?

Does the combination of droperidol and ondansetron reduce postoperative nausea and vomiting compared to either drug alone in patients undergoing major gynaecological surgery?

Population

90 patients undergoing major gynaecological procedures under combined general and epidural anaesthesia

Comparison

Combination of droperidol 1.25 mg i.v. and… vs Droperidol 1.25 mg i.v. alone or ondansetron 4…

Design

RCT, randomized, double-blind

Follow-up

24 hours

Authors

APAldo J. PeixotoYale New Haven HospitalAFA. J. Peixoto FilhoYale UniversityLLL. Leaes

Discussion

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Overview

Supports early combination use for PONV in gynaecological surgery; extends single-agent data without improving 24-hour incidence.

Structured PICO

Does the combination of droperidol and ondansetron reduce postoperative nausea and vomiting compared to either drug alone in patients undergoing major gynaecological surgery?

P
Population
90 patients undergoing major gynaecological procedures under combined general and epidural anaesthesia
I
Intervention
Combination of droperidol 1.25 mg i.v. and ondansetron 4 mg i.v. (n=30)
C
Comparator
Droperidol 1.25 mg i.v. alone (n=30) or ondansetron 4 mg i.v. alone (n=30)
O
Outcome
Postoperative nausea and vomiting (PONV) in the first 24 h (analysed by linear nausea/vomiting score, incidence of nausea and vomiting, and need for antiemetic rescue)patient reported

The combination of droperidol and ondansetron provides slightly better early prevention of postoperative nausea and vomiting than either drug alone in major gynaecological surgery.

Cite This Study

Peixoto et al. (2000) studied this question.

synapsesocial.com/papers/6a81bf9a6494b7aed7bf6efbhttps://doi.org/10.1046/j.1365-2346.2000.00726.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Comparison of Costs and Efficacy of Ondansetron and Droperidol as Prophylactic Antiemetic Therapy for Elective Outpatient Gynecologic Procedures1996 · 140 citations
  2. 2A Comparison of Costs and Efficacy of Ondansetron and Droperidol as Prophylactic Antiemetic Therapy for Elective Outpatient Gynecologic Procedures1996 · 168 citations
  3. 3Ondansetron, droperidol and their combination for the prevention of post-operative vomiting in children1997 · 41 citations
  4. 4Comparison of Ondansetron and Droperidol in the Prevention of Nausea and Vomiting After Inpatient Minor Gynecologic Surgery1995 · 55 citations
  5. 5Ondansetron Prevents Postoperative Nausea and Vomiting in Women Outpatients1994 · 70 citations