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July 1, 1997European Journal of Anaesthesiology

Ondansetron, droperidol and their combination for the prevention of post-operative vomiting in children

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Why the study?

Does droperidol, ondansetron, or their combination prevent post-operative vomiting in children undergoing surgery for strabismus?

Population

160 ASA Grade I and II children undergoing surgery for strabismus

Comparison

Droperidol 75 μg kg−1, ondansetron 0.1 mg kg−1… vs NaCl as placebo

Design

RCT, randomly assigned to one of four groups

Follow-up

24 h

Authors

AKA. P. Klockgether‐RadkeUniversitätsmedizin GöttingenSNSabine NeumannUniversität HamburgPNPeter NeumannTufts Medical Center

Discussion

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Implication

Either agent alone suffices to prevent emesis after pediatric strabismus surgery; confirms no additive benefit from combination.

Structured PICO

Does droperidol, ondansetron, or their combination prevent post-operative vomiting in children undergoing surgery for strabismus?

P
Population
160 ASA Grade I and II children undergoing surgery for strabismus
I
Intervention
Droperidol 75 μg kg−1, ondansetron 0.1 mg kg−1, or their combination (droperidol 75 μg kg−1 and ondansetron 0.1 mg kg−1)
C
Comparator
NaCl as placebo
O
Outcome
Emesis within the first 24 hpatient reported

Droperidol and ondansetron are equally effective at reducing post-operative vomiting in children undergoing strabismus surgery, and their combination offers no additional benefit.

Cite This Study

Klockgether‐Radke et al. (1997) studied this question.

synapsesocial.com/papers/6a8a85da3eb0001306cbeb45https://doi.org/10.1097/00003643-199707000-00004
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ondansetron in the Treatment of Postoperative Vomiting1992 · 150 citations
  2. 2Ondansetron Reduces the Incidence and Severity of Poststrabismus Repair Vomiting in Children1994 · 92 citations
  3. 3Comparison of Ondansetron Versus Placebo to Prevent Postoperative Nausea and Vomiting in Women Undergoing Ambulatory Gynecologic Surgery1993 · 298 citations
  4. 4The effect of oral ondansetron in the prevention of postoperative nausea and vomiting after major gynaecological surgery performed under general anaesthesia1993 · 62 citations
  5. 5Comparison of the 5-Hydroxytryptamine 3 (Serotonin) Antagonist Ondansetron (Gr 38032F) with High-Dose Metoclopramide in the Control of Cisplatin-Induced Emesis1990 · 412 citations