January 1, 1970Journal of Nepal Medical AssociationOpen Access

A Comparative Study of Ondansetron Versus Metoclopramide in the Prevention of Post-Operative Vomiting in Routine Major Gynecological Surgery Under General Anesthesia

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Why the study?

Does ondansetron reduce post-operative vomiting and the need for rescue antiemetics compared to metoclopramide in patients undergoing major gynecological surgery?

Population

60 patients of American Society of Anaesthesiologist I and ASA II undergoing routine major gynecological…

Comparison

Ondansetron 8 mg I.V. diluted to 5 ml of normal… vs Metoclopramide 10 mg I.V. diluted to 5 ml of…

Design

RCT, randomized, double blinded

Follow-up

24 hours

Authors

BSBabu Raja ShresthaKathmandu Medical College Teaching Hospital

Discussion

Member takes

Overview

May support ondansetron preference in gynecologic surgery; leaves open need for larger confirmatory trials.

Structured PICO

Does ondansetron reduce post-operative vomiting and the need for rescue antiemetics compared to metoclopramide in patients undergoing major gynecological surgery?

Population

60 patients of American Society of Anaesthesiologist (ASA) I and ASA II undergoing routine major gynecological surgery (Transabdominal Hysterectomy, laprotomy and cystectomy, tubal surgery) under general anesthesia.

Intervention

Ondansetron 8 mg I.V. diluted to 5 ml of normal saline given prior to induction of anesthesia.

Comparator

Metoclopramide 10 mg I.V. diluted to 5 ml of normal saline given prior to induction of anesthesia.

Outcome

Frequencies of vomiting and requirement of rescue antiemetics in the first 24 hours post-operative.

Ondansetron 8 mg IV is more effective than metoclopramide 10 mg IV in preventing post-operative nausea and vomiting in patients undergoing major gynecological surgery.

Limitations

small sample size

Cite This Study

Babu Raja Shrestha (1970) studied this question.

synapsesocial.com/papers/6aa90947b17909331cd92519 https://doi.org/10.31729/jnma.431

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January 1, 1970Journal of Nepal Medical AssociationOpen Access

A Comparative Study of Ondansetron Versus Metoclopramide in the Prevention of Post-Operative Vomiting in Routine Major Gynecological Surgery Under General Anesthesia

View Full Paper

Ask AI

Bookmark

Why the study?

Does ondansetron reduce post-operative vomiting and the need for rescue antiemetics compared to metoclopramide in patients undergoing major gynecological surgery?

Population

60 patients of American Society of Anaesthesiologist I and ASA II undergoing routine major gynecological…

Comparison

Ondansetron 8 mg I.V. diluted to 5 ml of normal… vs Metoclopramide 10 mg I.V. diluted to 5 ml of…

Design

RCT, randomized, double blinded

Follow-up

24 hours

Authors

BSBabu Raja ShresthaKathmandu Medical College Teaching Hospital

Discussion

Member takes

Overview

May support ondansetron preference in gynecologic surgery; leaves open need for larger confirmatory trials.

Structured PICO

Does ondansetron reduce post-operative vomiting and the need for rescue antiemetics compared to metoclopramide in patients undergoing major gynecological surgery?

Population

Intervention

Ondansetron 8 mg I.V. diluted to 5 ml of normal saline given prior to induction of anesthesia.

Comparator

Metoclopramide 10 mg I.V. diluted to 5 ml of normal saline given prior to induction of anesthesia.

Outcome

Frequencies of vomiting and requirement of rescue antiemetics in the first 24 hours post-operative.

Ondansetron 8 mg IV is more effective than metoclopramide 10 mg IV in preventing post-operative nausea and vomiting in patients undergoing major gynecological surgery.

Limitations

small sample size

Cite This Study

Babu Raja Shrestha (1970) studied this question.

synapsesocial.com/papers/6aa90947b17909331cd92519 https://doi.org/10.31729/jnma.431

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

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