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January 1, 1993AnesthesiologyOpen Access

Comparison of Ondansetron Versus Placebo to Prevent Postoperative Nausea and Vomiting in Women Undergoing Ambulatory Gynecologic Surgery

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Why the study?

Does intravenous ondansetron reduce the incidence of postoperative nausea and emesis in women undergoing ambulatory gynecologic surgery?

Population

544 women between the ages of 18 and 70 yr undergoing gynecologic surgical procedures with general opioid…

Comparison

Intravenous ondansetron administered prior to… vs Placebo administered prior to induction of…

Design

RCT, Randomized to dose received, stratified according to history of nausea…

Follow-up

24 hours

Authors

RMRay McKenzieSwinburne University of TechnologyAKAnthony L. KovacThe University of Texas MD Anderson Cancer CenterTOThomas A. O’ConnorOlivet Nazarene University

Discussion

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Overview

Supports ondansetron 4- or 8-mg dosing for PONV prophylaxis in ambulatory gynecologic surgery; confirms efficacy versus placebo in this RCT.

Structured PICO

Does intravenous ondansetron reduce the incidence of postoperative nausea and emesis in women undergoing ambulatory gynecologic surgery?

P
Population
544 women between the ages of 18 and 70 yr undergoing gynecologic surgical procedures with general opioid anesthesia on an outpatient basis
I
Intervention
Intravenous ondansetron (1, 4, or 8 mg) administered prior to induction of anesthesia
C
Comparator
Placebo administered prior to induction of anesthesia
O
Outcome
Incidence of nausea and emesis during the 24-h postoperative period (until 24 h after recovery room entry)patient reported

Intravenous ondansetron, particularly at 4- and 8-mg doses, is highly effective and well-tolerated for preventing postoperative nausea and emesis in women undergoing ambulatory gynecologic surgery.

Cite This Study

McKenzie et al. (1993) studied this question.

synapsesocial.com/papers/6a6fa2ca5d37378ac1dcb1behttps://doi.org/10.1097/00000542-199301000-00005
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Single dose intravenous ondansetron in the prevention of postoperative nausea and vomiting1994 · 145 citations
  2. 2Ondansetron 4 mg for the Prevention of Nausea and Vomiting after Minor Laparoscopic Gynaecological Surgery1994 · 36 citations
  3. 3Ondansetron is effective in decreasing postoperative nausea and vomiting1992 · 27 citations
  4. 4The effect of oral ondansetron in the prevention of postoperative nausea and vomiting after major gynaecological surgery performed under general anaesthesia1993 · 62 citations
  5. 5Intravenous Ondansetron for Postsurgical Opioid-Induced Nausea and Vomiting1997 · 28 citations