Key result
Oral ondansetron 8 mg significantly reduced the incidence of postoperative nausea and/or vomiting compared to placebo (56% vs 78%, p < 0.001) following major gynaecological surgery.
Why the study?
Does oral ondansetron prevent postoperative nausea and vomiting in patients undergoing major gynaecological surgery under general anaesthesia?
Population
243 patients undergoing major gynaecological surgery under general anaesthesia
Comparison
Oral ondansetron 8 mg, three doses at 8-hourly… vs Matching placebo at 8-hourly intervals
Design
RCT, randomised, double-blind
Follow-up
24 h postrecovery period
Authors
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Supports oral ondansetron prophylaxis in major gynaecological surgery; confirms RCT efficacy for PONV reduction in high-risk patients.
RCT (n=243)
double-blind
randomised
Yes
Does oral ondansetron prevent postoperative nausea and vomiting in patients undergoing major gynaecological surgery under general anaesthesia?
Absolute Event Rate: 56% vs 78%
p-value: p=< 0.001
Oral ondansetron 8 mg given in three doses starting before surgery significantly reduces the incidence and severity of postoperative nausea and vomiting after major gynaecological surgery.
Dupeyron et al. (1993) conducted an RCT in postoperative nausea and vomiting (n=243). oral ondansetron vs. matching placebo was evaluated on postoperative nausea and/or vomiting (p=< 0.001). Oral ondansetron 8 mg significantly reduced the incidence of postoperative nausea and/or vomiting compared to placebo (56% vs 78%, p < 0.001) following major gynaecological surgery.
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