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January 1, 1994Anaesthesia

Single dose intravenous ondansetron in the prevention of postoperative nausea and vomiting

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Why the study?

Does prophylactic intravenous ondansetron prevent postoperative nausea and vomiting in patients undergoing outpatient surgery?

Population

Male and female patients scheduled to undergo outpatient surgery on a day case basis

Comparison

Intravenous ondansetron administered prior to… vs Placebo administered prior to induction of…

Design

Other

Follow-up

24 hours postoperatively

Authors

MPMichael H. PearmanPhillips 66 (United States)

Discussion

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Overview

Supports ondansetron 4 mg prophylaxis for PONV in outpatient surgery; confirms efficacy across sexes in RCT.

Structured PICO

Does prophylactic intravenous ondansetron prevent postoperative nausea and vomiting in patients undergoing outpatient surgery?

P
Population
Male and female patients scheduled to undergo outpatient surgery on a day case basis (n=1,637; 1,169 females and 468 males)
I
Intervention
Intravenous ondansetron (1 mg, 4 mg, or 8 mg) administered prior to induction of anaesthesia
C
Comparator
Placebo administered prior to induction of anaesthesia
O
Outcome
Prevention of emesis (postoperative nausea and vomiting) over 24 hours postoperatively

Prophylactic intravenous ondansetron 4 mg is safe and effective for the prevention of postoperative nausea and vomiting in patients undergoing day case surgery.

Cite This Study

Michael H. Pearman (1994) studied this question.

synapsesocial.com/papers/6a8924f54f37e970fb7b47bdhttps://doi.org/10.1111/j.1365-2044.1994.tb03577.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of Ondansetron Versus Placebo to Prevent Postoperative Nausea and Vomiting in Women Undergoing Ambulatory Gynecologic Surgery1993 · 298 citations
  2. 2Ondansetron is effective in decreasing postoperative nausea and vomiting1992 · 27 citations
  3. 3The effect of oral ondansetron in the prevention of postoperative nausea and vomiting after major gynaecological surgery performed under general anaesthesia1993 · 62 citations
  4. 4Ondansetron 4 mg for the Prevention of Nausea and Vomiting after Minor Laparoscopic Gynaecological Surgery1994 · 36 citations
  5. 5The Effect of Timing of Ondansetron Administration on Its Efficacy, Cost-Effectiveness, and Cost-Benefit as a Prophylactic Antiemetic in the Ambulatory Setting1998 · 167 citations