Why the study?
Does ondansetron 4 mg IV administered after surgery reduce postoperative nausea and vomiting in healthy women undergoing outpatient gynecological laparoscopy?
Population
164 healthy women undergoing outpatient gynecological laparoscopic procedures with a standardized anesthetic
Comparison
Ondansetron 4 mg IV administered after surgery… vs Placebo (Group A)
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
24 hours postoperatively
Authors
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May support ondansetron administration at surgery end in outpatient laparoscopy; extends evidence on optimal 5-HT3 antagonist timing.
Does ondansetron 4 mg IV administered after surgery reduce postoperative nausea and vomiting in healthy women undergoing outpatient gynecological laparoscopy?
Administering ondansetron 4 mg IV at the end of surgery rather than before induction provides superior efficacy in preventing postoperative nausea and vomiting and improves recovery in outpatient laparoscopy.
Tang et al. (1998) studied this question.
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