Why the study?
Although leiomodin is essential for life and an emerging regulator of thin filaments, numerous domains within leiomodin remain unstudied.
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Design
Review
Leiomodin mechanisms in actin dynamics remain hypothetical; leaves open validation in cardiac sarcomere models.
Leiomodin is an important emerging regulator of thin filaments. As novel molecular, cellular, animal model, and human data accumulate, the mechanisms of its action become clearer. Structural studies played a significant part in understanding the functional significance of leiomodin's interacting partners and functional domains. In this review, we present the current state of knowledge on the structural and cellular properties of leiomodin which has led to two proposed mechanisms of its function. Although it is known that leiomodin is essential for life, numerous domains within leiomodin remain unstudied and as such, we outline future directions for investigations that we predict will provide evidence that leiomodin is a multifunctional protein.
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Tolkatchev et al. (2021) studied this question.
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