Subtle extrapyramidal signs and incident dementia

We previously reported [1] that the presence of mild extrapyramidal signs (EPS) significantly predicts Alzheimer's disease (AD) in elderly individuals, independent of age, education, or gender. We now report a confirmation of our data after accrual of more cases and additional follow-up assessments. ### Methods. Two hundred twenty-six normal elderly controls from the Washington Heights-Inwood Columbia Aging Project studied by Richards et al [1] were the subjects for follow-up. Data for these subjects accrued since October 1992 were added, and five additional subjects, previously with baseline data only, underwent at least one follow-up assessment. EPS were measured using a modified version of the …