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The utility of 1,2,3,4-tetrahydropyrimidine-5-carboxylate (1a,b), and 1,2-dihydropyrimidine-5-carboxylate (2) in the synthesis of some new functionalized pyrimidine derivatives such as 6-Antimicrobial evaluation of some selected examples from the synthesized products was carried out and showed promising results.Pyrimidine derivatives are reported to possess antibacterial, 1-3 antifungal 4,5 anticancer, 6,7 antiinflammatory, 8,9 and cardioprotective effects. 10In addition, certain pyrimidine derivatives are known to display antimalarial, antifilarial and antileshmainal activities. 11Also, pyrimidine nucleus is considered as
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Kheder et al. (2011) studied this question.
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