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A single dose of 2 Bro-α-ergocryptine (CB-154) lowers serum prolactin for at least 12 hrs. in normal subjects. CB-154 in the immediate postpartum period causes a marked suppression of the elevated serum prolactin levels and completely inhibits puerperal lactation and breast engorgement. In patients with galactorrhea and elevated serum prolactin values the ergot alkaloid effectively lowers serum prolactin concentrations leading to a cessation of the galactorrhea.
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Pozo et al. (1972) studied this question.
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