Gametes and embryos are natural sources of free radicals. When manipulated in vitro during assisted reproductive techniques, these cells run the risk of generating and being exposed to supraphysiological levels of reactive oxygen species. It is therefore clear that free radicals and oxidative stress can have a significant impact on IVF outcome. This review summarizes the role of oxidative stress in the etiology and pathophysiology of human IVF, as well as considering different strategies and approaches to be followed to prevent the harmful effects of oxidative stress on IVF.
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Plessis et al. (2008) studied this question.
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