Cutaneous Absorption of Sex Hormones

Despite some previous reports on the effects of hormones when applied to external surfaces,1there is yet a lack of appreciation of the readiness with which such substances are taken up by the skin and become effective in the body. This is of importance because hormones are at present available in ordinary commercial items such as face creams. A realization of their ready entrance into the body and some measure of their effects after entering the body should therefore be understood. The following brief account is devoted to presenting some of our experiences in applying both androgens and estrogens in a lanolin-like menstruum or cream to the skin of experimental animals. APPLICATION OF ANDROGENS We have employed testosterone and testosterone propionate in a concentration of 50 mg. per ounce of cream.2Treatment has usually been limited to one daily application on areas of shaved skin of from 2