The sexual glands and metabolism

ISCOVESCOwas the first investigatorto study thelipoids of the gonads [1912,1, 2]. He [1907-1914] extracted the lipoids of several tissues and glands, including the testis, and came to the conclusion that all the organs which he had investigated contained at least one specific lipoid which, when introduced into the organism, caused an increase in the function of the organ from which the lipoid had been isolated. Iscovesco therefore called these lipoids homostimulines. From a -study of the action of various fractions of the lipoids he concluded that some of them are physiologically indifferent, others antagonistic to homo- stimulines. These he called heterostimulines.