Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 21, 2025Frontiers in Cardiovascular MedicineOpen Access

Mechanism and research progress of MAPK signaling pathway in myocardial fibrosis

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Myocardial fibrosis is a hallmark pathological outcome of many cardiovascular diseases and a key component of cardiac remodeling, with MAPK signaling pathways being central to this process.

Design

Review

Authors

JWJinqiao WuMCMin ChenZPZe Peng

Discussion

Loading...

Member takes

Overview

Identifies MAPK targets for myocardial fibrosis therapy; leaves open clinical translation pending prospective trials.

Structured PICO

P
Population
Myocardial fibrosis
I
Intervention
Drug and non-pharmacological therapies targeting p38 MAPK, JNK, and ERK signaling pathways

The p38 MAPK, JNK, and ERK signaling pathways play a central role in myocardial fibrosis and represent potential therapeutic targets.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/6a892cf503fab2a419a5f682https://doi.org/10.3389/fcvm.2025.1667568
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Myocardial Fibrosis: Assessment, Quantification, Prognostic Signification, and Anti-Fibrosis Targets: A State-of-the-Art Review2025 · 15 citations
  2. 2Qishen granule attenuates cardiac fibrosis by regulating TGF-β /Smad3 and GSK-3β pathway2019 · 110 citations
  3. 3Interleukin‑22 is elevated in the atrium and plasma of patients with atrial fibrillation and increases collagen synthesis in transforming growth factor‑β1‑treated cardiac fibroblasts via the JNK pathway2020 · 5 citations
  4. 4Activation of p38α MAPK Enhances Collagenase-1 (Matrix Metalloproteinase (MMP)-1) and Stromelysin-1 (MMP-3) Expression by mRNA Stabilization2002 · 221 citations
  5. 5Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology2018 · 1,111 citations