Key result
Qishen Granule improved cardiac function and reduced cardiac fibrosis in a rat model of heart failure, potentially by inhibiting the TGF-β/Smad3 pathway and GSK-3β phosphorylation.
Why the study?
Although Qishen Granule has demonstrated therapeutic effects on cardiac fibrosis in heart failure, its underlying mechanisms remain unclear.
Does Qishen Granule improve heart function and attenuate cardiac fibrosis in a rat model of heart failure?
Does Qishen Granule improve heart function and attenuate cardiac fibrosis in a rat model of heart failure?
Qishen Granule improves cardiac function and attenuates cardiac fibrosis in a rat model of heart failure, potentially by inhibiting the TGF-β/Smad3 pathway and GSK-3β phosphorylation.
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Provides preclinical support for Qishen Granule in heart failure; leaves open translation to human therapy.
Zeng et al. (2019) studied Heart failure. Qishen Granule (QSG) vs. Sham group, model group, and Fosinopril control group was evaluated on Cardiac function (EF and FS) and degree of cardiac fibrosis. Qishen Granule improved cardiac function and reduced cardiac fibrosis in a rat model of heart failure, potentially by inhibiting the TGF-β/Smad3 pathway and GSK-3β phosphorylation.
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