Key result
Qishen granules significantly improved cardiac function in heart failure rats, increasing left ventricular ejection fraction to 49.11% compared to 34.60% in the model group.
Why the study?
Although Qishen granules (QSG) have been applied to treat heart failure (HF) and suggested to regulate cardiac energy metabolism pathways, the specific regulatory mechanism has not been clarified.
Does Qishen granules improve cardiac function and energy metabolism in a rat model of heart failure?
Population
Rat model of HF induced by left anterior descending coronary artery ligation
Comparison
QSG treatment in a rat model of HF
Design
Preclinical animal study
Authors
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Hypothesis-generating in rat heart failure; leaves open clinical translation pending human trials.
Does Qishen granules improve cardiac function and energy metabolism in a rat model of heart failure?
Absolute Event Rate: 49.11% vs 34.6%
p-value: p=<0.05
Qishen granules exert cardioprotective effects in a rat model of heart failure by improving myocardial energy metabolism through increased fatty acid metabolism and stimulated glucose oxidation.
Gao et al. (2020) studied Heart failure (n=60). Qishen granules (QSG) vs. Normal saline was evaluated on Left ventricular ejection fraction (EF) (p=<0.05). Qishen granules significantly improved cardiac function in heart failure rats, increasing left ventricular ejection fraction to 49.11% compared to 34.60% in the model group.
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