What is the clinical evidence from this study?

Study design: Other. Population: Heart failure. Intervention: Qishenyiqi formula (QSYQ) vs. Vehicle. Primary outcome: Cardiac function, mitochondrial function, and metabolic remodeling.

What question did this study set out to answer?

This study investigates how the Qishen Yiqi Formula (QSYQ) improves heart function in heart failure induced by transverse aortic constriction (TAC).

May 2, 2026

Qishen Yiqi Formula Mitigates Heart Failure by Restoring Myocardial Energy Metabolism via AMPK: Insights from Multi-Omics Analysis.

View Full Paper

Ask AI

Bookmark

Key result

Qishenyiqi formula mitigates heart failure in mice by improving mitochondrial bioenergetics via the AMPK/PPARα/PGC-1α pathway.

Why the study?

The mechanisms of Qishenyiqi formula in modulating substrate utilization and metabolic remodeling in transverse aortic constriction-induced heart failure remain unclear.

Does Qishenyiqi formula (QSYQ) improve cardiac function and metabolic remodeling in TAC-induced heart failure mice?

Population

TAC-induced HF mice

Comparison

QSYQ (1170 or 585 mg/kg) vs vehicle

Design

Preclinical animal study

Follow-up

Four weeks

Authors

YWYuting WangTianjin University of Traditional Chinese Medicine TNTong NieTianjin University of Traditional Chinese Medicine XCXinting ChenTianjin University of Traditional Chinese Medicine

Discussion

Member takes

Implication

Should not change clinical HF practice; leaves open QSYQ's metabolic effects for human translational studies.

Key Points

This study investigates how the Qishen Yiqi Formula (QSYQ) improves heart function in heart failure induced by transverse aortic constriction (TAC).
TAC-induced heart failure mice were treated with QSYQ (1170 or 585 mg/kg) or vehicle for four weeks.
Cardiac function was evaluated using echocardiography, hemodynamic measurements, and histopathology.
Integrated proteomics and metabolomics analyses identified key metabolic pathways affected by QSYQ.
QSYQ improved ejection fraction and hemodynamics while reducing cardiac hypertrophy and fibrosis.
Mitochondrial integrity and function improved, indicated by increased ATP synthesis and reduced reactive oxygen species.
Multi-omics analysis demonstrated QSYQ's modulation of myocardial metabolism via the AMPK/PPARα/PGC-1α pathway.

Structured PICO

Does Qishenyiqi formula (QSYQ) improve cardiac function and metabolic remodeling in TAC-induced heart failure mice?

Population

Transverse aortic constriction (TAC)-induced heart failure mice

Intervention

Qishenyiqi formula (QSYQ) 1170 or 585 mg/kg for four weeks

Comparator

Vehicle

Outcome

Cardiac function (assessed through echocardiography, hemodynamic measurements), histopathology, fibrosis analysis, heart failure biomarkers (ANP and BNP), and mitochondrial functionsurrogate

Qishenyiqi formula mitigates TAC-induced heart failure in mice by improving mitochondrial bioenergetics and metabolic remodeling through the AMPK/PPARα/PGC-1α pathway.

Cite This Study

Wang et al. (2026) studied Heart failure. Qishenyiqi formula (QSYQ) vs. Vehicle was evaluated on Cardiac function, mitochondrial function, and metabolic remodeling. Qishenyiqi formula mitigated TAC-induced heart failure in mice by improving mitochondrial bioenergetics and metabolic remodeling through the AMPK/PPARα/PGC-1α pathway.

synapsesocial.com/papers/69f5945c71405d493afff1f7 https://doi.org/10.2174/0113816128425280251112150246

Topics

HFrEF treatment Heart failure HFpEF management

View Full Paper

Ask AI

Bookmark

Qishen Yiqi Formula Mitigates Heart Failure by Restoring Myocardial Energy Metabolism via AMPK: Insights from Multi-Omics Analysis.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Qishen Yiqi Formula Mitigates Heart Failure by Restoring Myocardial Energy Metabolism via AMPK: Insights from Multi-Omics Analysis.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider