Key result
Shen-Fu formula significantly alleviated myocardial fibrosis and hypertrophy, improved cardiac function, and synergistically mediated the metabolic flexibility of fatty acids and glucose in TAC-induced heart failure mice.
Why the study?
Targeting cardiac metabolic remodeling has therapeutic potential in heart failure, and Shen-Fu formula is a promising combinatorial therapy whose therapeutic targets and cardioprotective mechanisms required investigation.
Does Shen-Fu formula improve cardiac function and attenuate metabolic remodeling in a mouse model of pressure overload-induced heart failure?
Population
Heart failure mice induced by transverse aortic constriction
Comparison
Shen-Fu formula treatment vs comparator
Design
Untargeted multi-omics animal study
Authors
Loading...
Preclinical multi-omics data on Shen-Fu in HF mice; leaves open clinical translation and efficacy in patients.
Does Shen-Fu formula improve cardiac function and attenuate metabolic remodeling in a mouse model of pressure overload-induced heart failure?
Shen-Fu formula attenuates cardiac metabolic remodeling and improves heart function in a mouse model of pressure overload-induced heart failure by regulating fatty acid and glucose metabolism via AMPK activation.
Huang et al. (2020) studied Heart failure (n=249). Shen-Fu formula (S-F) vs. TAC (model) and valsartan was evaluated on Cardiac function and metabolic remodeling. Shen-Fu formula significantly alleviated myocardial fibrosis and hypertrophy, improved cardiac function, and synergistically mediated the metabolic flexibility of fatty acids and glucose in TAC-induced heart failure mice.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: