Key result
Shengxian decoction significantly improved cardiac function, attenuated myocardial injury, and restored energy metabolism in a rat model of chronic heart failure, potentially via the AMPK/PGC-1α signaling pathway.
Why the study?
Imbalanced myocardial energy metabolism plays a key role in CHF, but the effects of Shengxian decoction on energy metabolism in CHF remained unclear.
Does Shengxian decoction improve cardiac function and energy metabolism in a rat model of chronic heart failure?
Population
SD rats
Comparison
Sham vs model vs trimetazidine vs high-, middle-, and low-dose SXT
Design
Randomized animal study
Authors
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SXT may improve myocardial energy metabolism in experimental CHF; leaves open translation to human therapy.
Does Shengxian decoction improve cardiac function and energy metabolism in a rat model of chronic heart failure?
p-value: p=<0.01
Shengxian decoction reverses CHF-induced cardiac dysfunction and maintains myocardial structure in rats by regulating energy metabolism via the PGC-1α signaling pathway.
Yang et al. (2023) studied Chronic heart failure (n=48). Shengxian decoction (SXT) vs. Saline (model group) and Trimetazidine (positive control) was evaluated on Cardiac function (Ejection Fraction and Fractional Shortening) and energy metabolism markers (p=<0.01). Shengxian decoction significantly improved cardiac function, attenuated myocardial injury, and restored energy metabolism in a rat model of chronic heart failure, potentially via the AMPK/PGC-1α signaling pathway.
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