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March 7, 2013Italian Journal of MedicineOpen Access

Clinical management of spontaneous intracranial haemorrhage associated with oral anticoagulants: a case series

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Population

15 patients hospitalized for spontaneous oral anticoagulant-related intracranial haemorrhage between January…

Design

Case_series

Follow-up

3 months after discharge

Authors

LMLuca MasottiAPAlessandro PampanaPPPaolo Pennati

Discussion

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Overview

High mortality in OAT-related ICH with low GCS or large volume signals poor prognosis; case-report data leaves open standardized reversal protocols.

Structured PICO

P
Population
15 patients hospitalized for spontaneous oral anticoagulant (OAT)-related intracranial haemorrhage (ICH) between January 2006 and January 2010.
I
Intervention
Reversal of oral anticoagulation therapy using various strategies including three-factor prothrombin complex concentrate (PCC), fresh frozen plasma (FFP), recombinant activated factor VII (FVIIra), and intravenous vitamin K1.
O
Outcome
Mortality and effectiveness of OAT reversal within 8 hours.hard clinical

In patients with OAT-related intracranial hemorrhage, mortality is high (46.5%) and strongly associated with hematoma size and initial Glasgow Coma Scale, highlighting the need for standardized, rapid reversal protocols.

Cite This Study

Masotti et al. (2013) studied this question.

synapsesocial.com/papers/6a892d2f4f37e970fb7b4984https://doi.org/10.4081/itjm.2011.34
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Also Consider

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  1. 1Prothrombin Complex Concentrates for Urgent Anticoagulation Reversal in Patients with Intracranial Haemorrhage2007 · 50 citations
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  3. 3Rapid Reversal of Anticoagulation Reduces Hemorrhage Volume in a Mouse Model of Warfarin-Associated Intracerebral Hemorrhage2009 · 34 citations
  4. 4Experimental Model of Warfarin-Associated Intracerebral Hemorrhage2008 · 110 citations
  5. 5Warfarin use leads to larger intracerebral hematomas2008 · 260 citations