August 1, 2026Acta Biochimica et Biophysica SinicaOpen Access

Pannexin 1 drives cardiac fibroblast activation and fibrosis via the ATP-purinergic receptor-JAK2/STAT3 axis in heart failure

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Pannexin 1 promotes cardiac fibroblast activation and fibrosis in heart failure through the ATP-purinergic receptor-JAK2/STAT3 signaling axis. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

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Key result

Pannexin 1 promotes heart failure fibrosis via the ATP-purinergic receptor-JAK2/STAT3 signaling axis.

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LQLieyang QinSun Yat-sen University YZYunjing ZhangCenter for Veterinary Medicine DADiyaerjiang AierkenSun Yat-sen University

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Qin et al. (2026) studied this question. Pannexin 1 drives cardiac fibroblast activation and fibrosis via the ATP-purinergic receptor-JAK2/STAT3 axis in heart failure.

synapsesocial.com/papers/6a892d833981116ebf4d3490 https://doi.org/10.3724/abbs.2026147

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Pannexin 1 drives cardiac fibroblast activation and fibrosis via the ATP-purinergic receptor-JAK2/STAT3 axis in heart failure

Discussion

Member takes

Implication

Key Points

Cite This Study

Pannexin 1 drives cardiac fibroblast activation and fibrosis via the ATP-purinergic receptor-JAK2/STAT3 axis in heart failure

Discussion

Member takes

Implication

Key Points

Cite This Study

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