Why the study?
Does chlorogenic acid attenuate ventricular remodeling after myocardial infarction in a murine model?
Population
Seven to nine week-old C57BL/6 mice with myocardial infarction induced by permanent ligation of the left…
Comparison
Chlorogenic acid 30 mg/kg/day administered orally vs Vehicle
Design
Preclinical, randomly assigned into 4 groups
Follow-up
14 days
Authors
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May support chlorogenic acid for post-MI remodeling in mice; leaves open clinical translation pending human trials.
Does chlorogenic acid attenuate ventricular remodeling after myocardial infarction in a murine model?
Oral administration of chlorogenic acid attenuates chronic ventricular remodeling and myocardial fibrosis after myocardial infarction in a murine model, likely by suppressing macrophage infiltration.
Kanno et al. (2013) studied this question.
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