Population
Experimental model of fracture healing
Comparison
Bolus intravenous administration of nitric oxide… vs Contralateral uninjured limbs and different time…
Design
Preclinical
Follow-up
28 days
Authors
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May support nitric oxide's role in early fracture vascular recovery; hypothesis-generating in animals and should not change practice.
Nitric oxide mediated vasoreactivity is maximal in the early phase of fracture healing, suggesting it plays a role in the initial restoration of blood flow.
Corbett et al. (1999) studied this question.
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