Why the study?
Does intracoronary infusion of allogeneic mesenchymal precursor cells improve cardiac function and reduce infarct size in a sheep model of acute myocardial infarction?
Population
88 sheep (20 for optimization, 68 in randomized study) with experimental anterior acute myocardial infarction
Comparison
Intracoronary infusion of allogeneic mesenchymal… vs Control group
Design
Preclinical, randomized
Follow-up
8 weeks
Authors
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MPC infusion aids ovine post-MI recovery; leaves open translation to human trials.
Does intracoronary infusion of allogeneic mesenchymal precursor cells improve cardiac function and reduce infarct size in a sheep model of acute myocardial infarction?
Intracoronary infusion of allogeneic mesenchymal precursor cells directly after acute myocardial infarction in a sheep model is safe, improves cardiac function, and reduces infarct size and adverse remodeling.
Houtgraaf et al. (2013) studied this question.
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