Key result
Intracoronary mononuclear cells cut post-MI infarct size by ~3% without improving LV function.
Why the study?
Stem cell therapy after myocardial infarction has been studied in permanent coronary occlusion models, but its effect in reperfused MI models is unclear.
Does intracoronary administration of bone marrow or mononuclear cells improve LV function or reduce infarct size in a porcine model of reperfused MI?
Does intracoronary administration of bone marrow or mononuclear cells improve LV function or reduce infarct size in a porcine model of reperfused MI?
Intracoronary injection of mononuclear cells reduces infarct size but does not improve left ventricular function in a porcine model of reperfused myocardial infarction.
No LV functional benefit from intracoronary cells in reperfused porcine MI; extends prior models but leaves human translation open.
AIMS: Stem cell therapy after myocardial infarction (MI) has been studied in models of permanent coronary occlusion. We studied the effect of intracoronary administration of unselected bone marrow (BM) and mononuclear cells (MNC) in a porcine model of reperfused MI. METHODS AND RESULTS: In 34 swine, the left circumflex coronary artery was balloon-occluded for 2 h followed by reperfusion. Ten swine without MI served as controls. All swine underwent magnetic resonance imaging (MRI) 1 week post-MI. The next day, 10 of the 30 surviving MI swine received BM, 10 other MI swine received MNC, and the remaining MI swine received medium intracoronary. Four weeks later, all swine underwent a follow-up MRI. One week after MI, end-diastolic volume (92+/-16 mL) and left ventricular (LV) weight (78+/-12 g) were greater, whereas ejection fraction (40+/-8%) was lower than in controls (69+/-11 mL, 62+/-13 g, and 53+/-6%). Injection of BM or MNC had no effect on the MI-induced changes in global or regional LV-function. However, there was a significant reduction in infarct size 4 weeks after MNC injection (-6+/-3%) compared with the medium (-3+/-5%). CONCLUSION: Intracoronary injection of BM or MNC in swine does not improve regional or global LV-function 4 weeks after injection. However, a reduction in infarct-size was noted after MNC injection.
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Moelker et al. (2006) studied Reperfused myocardial infarction (n=44). Intracoronary unselected bone marrow (BM) or mononuclear cells (MNC) vs. Medium intracoronary was evaluated on Change in infarct size at 4 weeks. Intracoronary injection of mononuclear cells in a porcine model of reperfused MI significantly reduced infarct size (-6% vs -3% for medium) but did not improve LV function.
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