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Demonstrates reduced renal kallikrein-kinin system gene expression in hypertensive ISIAH rats, suggesting impaired glomerular circulation contributes to hypertension.
The transcriptional activity of genes was studied in the kidneys of hypertensive ISIAH and normotensive WAG rats in order to detect genes significantly expressed in the kidneys of just one of the strains. Gene expression profiling was performed on the Illumina RatRef-12 Expression BeadChip microarray platform. The expression of three genes ( Klk1 , Klk1c10 , and Kng1 ) related to the kallikrein-kinin system was significant in the WAG renal cortex but was not detected in hypertensive kidneys. The lower expression of these three genes and Gucy1a3 in the ISIAH renal cortex suggests the weakened function of the kallikrein-kinin system in hypertensive kidneys, which may cause blood circulation disturbances in renal glomeruli and mediate the development of hypertension in ISIAH rats. The functional annotation of the genes significantly expressed in the renal medulla of just one of the compared rat strains revealed genes involved in immune response regulation.
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Redina et al. (2015) studied this question.
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