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June 1, 1991Journal of Clinical InvestigationOpen Access

Antisense-mediated reduction in thrombospondin reverses the malignant phenotype of a human squamous carcinoma.

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Authors

VCValerie P. CastleUniversity of PittsburghJVJames VaraniUniversity of MichiganSFSuzanne FligielJohn D. Dingell VA Medical Center

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Castle et al. (1991) studied this question.

synapsesocial.com/papers/6a892f116ef699e80f1ff565https://doi.org/10.1172/jci115212
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cell surface thrombospondin is functionally essential for vascular smooth muscle cell proliferation1988 · 255 citations
  2. 2Effect of Antisense c- raf -1 on Tumorigenicity and Radiation Sensitivity of a Human Squamous Carcinoma1989 · 187 citations
  3. 3Platelet thrombospondin mediates attachment and spreading of human melanoma cells.1987 · 195 citations
  4. 4Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo.1988 · 208 citations
  5. 5Induction of thrombospondin messenger RNA levels occurs as an immediate primary response to platelet-derived growth factor.1987 · 140 citations