February 1, 1989Journal of Autonomic Pharmacology

Vascular smooth muscle responses in normo‐ and hypertensive rats to sympathetic nerve stimulation and putative transmitters

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Population

Tail artery and mesenteric bed preparations from normotensive (WKY) and spontaneously hypertensive (SHR) rats

Comparison

Field stimulation, noradrenaline (10-10 M)… vs Age-matched normotensive (WKY) control rats

Design

Preclinical

Authors

TMT C MuirUniversity of Strathclyde KWKay A. WardleNew Frontier

Discussion

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Implication

Suggests postsynaptic alpha-adrenoreceptor mediation of vascular hyperreactivity in SHR; leaves open human translation.

Structured PICO

Population

Tail artery and mesenteric bed preparations from normotensive (WKY) and spontaneously hypertensive (SHR) rats

Intervention

Field stimulation (0.5 ms supramaximal voltage), noradrenaline (10(-5)-10(-3) M), adrenaline (10(-6)-10(-4) M), and adenosine triphosphate (ATP, 10(-4)-10(-2) M)

Comparator

Age-matched normotensive (WKY) control rats

Outcome

Changes in perfusion pressure (pressor responses)surrogate

The increased vascular response to nerve stimulation in hypertensive rats is likely mediated postsynaptically via alpha-adrenoreceptors, with no evidence of ATP involvement in the hypertensive state.

Cite This Study

Muir et al. (1989) studied this question.

synapsesocial.com/papers/6a893079a80e40e0ce4d3360 https://doi.org/10.1111/j.1474-8673.1989.tb00193.x

View Full Paper

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Vascular smooth muscle responses in normo‐ and hypertensive rats to sympathetic nerve stimulation and putative transmitters

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Vascular smooth muscle responses in normo‐ and hypertensive rats to sympathetic nerve stimulation and putative transmitters

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider