What question did this study set out to answer?

To evaluate the immunomodulatory effects of oral IFN-tau alone and in combination with oral glatiramer acetate on disease suppression in experimental autoimmune encephalomyelitis.

September 1, 2002The Journal of ImmunologyOpen Access

Cutting Edge: Oral Type I IFN-τ Promotes a Th2 Bias and Enhances Suppression of Autoimmune Encephalomyelitis by Oral Glatiramer Acetate

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Authors

JSJeanne M. SoosGlaxoSmithKline (United States)OSOlaf StüveVA North Texas Health Care System SYSawsan YoussefTower Urology Medical Group

Discussion

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Implication

Experimental animal study demonstrates oral interferon-tau synergizes with glatiramer acetate to suppress autoimmune encephalomyelitis in mice, suggesting combination therapy for multiple sclerosis.

Key Points

To evaluate the immunomodulatory effects of oral IFN-tau alone and in combination with oral glatiramer acetate on disease suppression in experimental autoimmune encephalomyelitis.
Administered oral IFN-alpha, IFN-beta, or IFN-tau to myelin basic protein-specific TCR-transgenic mice to evaluate induction of Th1 and Th2 cytokines.
Treated wild-type mice with suboptimal oral doses of IFN-tau alone or in combination with glatiramer acetate in an experimental allergic encephalomyelitis model.
Oral IFN-tau stimulated secretion of the Th2 cytokine IL-10 with efficacy comparable to IFN-alpha and IFN-beta, but without inducing the Th1 cytokine IFN-gamma.
Oral IFN-tau alone suppressed experimental allergic encephalomyelitis.
Combined administration of suboptimal doses of oral IFN-tau and glatiramer acetate synergistically suppressed encephalomyelitis, accompanied by elevated TGF-beta and enhanced IL-10 secretion.

Cite This Study

Soos et al. (2002) studied this question.

synapsesocial.com/papers/6a8930ba46f665d098761285 https://doi.org/10.4049/jimmunol.169.5.2231

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Implication

Experimental animal study demonstrates oral interferon-tau synergizes with glatiramer acetate to suppress autoimmune encephalomyelitis in mice, suggesting combination therapy for multiple sclerosis.

Cutting Edge: Oral Type I IFN-τ Promotes a Th2 Bias and Enhances Suppression of Autoimmune Encephalomyelitis by Oral Glatiramer Acetate

Discussion

Member takes

Implication

Key Points

Cite This Study

Cutting Edge: Oral Type I IFN-τ Promotes a Th2 Bias and Enhances Suppression of Autoimmune Encephalomyelitis by Oral Glatiramer Acetate

Discussion

Member takes

Implication

Key Points

Cite This Study

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