Encephalomyocarditis virus replication and cytopathic effects are faster and more robust in S phase compared to G1 phase mouse embryo fibroblasts.
Cell-cycle effects on EMCV replication in fibroblasts are hypothesis-generating; leaves open in vivo or clinical relevance.
Infection of mouse embryo fibroblasts in G1 or S phase with encephalomyocarditis virus gave different kinetics of viral RNA synthesis. In S phase cells, RNA synthesis was faster and reached higher levels than in G1 cells. Virus-specified proteins were fewer in G1 cells than in S cells during the early stage of the infection and c.p.e. in G1 cells appeared about 4 h later than in S cells. Addition of a cellular factor with ability to affect cell conformation had an inhibitory effect on viral RNA synthesis.
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Mallucci et al. (1985) studied this question.
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