What does this research mean for the field?

During encephalomyocarditis virus infection of Krebs-2 ascites tumour cells, infective viral RNA is initially associated with the nuclear fraction before shifting to the mitochondrial fraction, where the majority of subsequent viral assembly occurs. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1963Journal of General Microbiology

Intracellular Sites of Synthesis of Encephalomyocarditis Virus Components in Krebs-2 Ascites Tumour Cells

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Population

Krebs-2 ascites tumour cells infected with encephalomyocarditis virus in vitro

Design

Preclinical

Follow-up

up to 8 hours post-infection

Authors

ABA. J. D. BellettAustralian National University ABA. T. H. BurnessMemorial University of Newfoundland

Discussion

Member takes

Implication

Provides no basis for altering myocarditis management; leaves open mitochondrial involvement in EMCV replication.

Structured PICO

Population

Krebs-2 ascites tumour cells infected with encephalomyocarditis virus in vitro

Intervention

Infection with encephalomyocarditis virus

Outcome

Intracellular localization of infective RNA, haemagglutinin, and plaque-forming virus over timesurrogate

The study maps the temporal and spatial synthesis of encephalomyocarditis virus components within Krebs-2 ascites tumour cells, showing a shift from nuclear to mitochondrial fractions.

Cite This Study

Bellett et al. (1963) studied this question.

synapsesocial.com/papers/6a1c0d791567d2fc4d5f82b4 https://doi.org/10.1099/00221287-30-1-131

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Intracellular Sites of Synthesis of Encephalomyocarditis Virus Components in Krebs-2 Ascites Tumour Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Intracellular Sites of Synthesis of Encephalomyocarditis Virus Components in Krebs-2 Ascites Tumour Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider