What question did this study set out to answer?

To determine the tissue distribution, intestinal re-entry, and metabolic fate of orally administered radiolabeled α-tocopherol in rats.

February 1, 1966British Journal Of NutritionOpen Access

The distribution and metabolism of α-tocopherol in the rat

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Authors

AMAlan MellorsUniversity of Guelph MBMargaret BarnesMarine Scotland

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Implication

Experimental animal study demonstrates high splenic and adrenal uptake of alpha-tocopherol in rats, indicating tissue retention without rapid gut re-entry.

Key Points

To determine the tissue distribution, intestinal re-entry, and metabolic fate of orally administered radiolabeled α-tocopherol in rats.
Administered oral doses of [5-Me-14C]-α-tocopherol to rats to monitor radioactivity distribution in tissue lipids over a 24-hour period.
Assessed biliary excretion and gastric mucosal secretion to evaluate the re-entry of absorbed compounds into the gut lumen.
Extracted and analyzed liver and spleen lipids to quantify unchanged α-tocopherol and identify downstream metabolic oxidation products.
Radioactivity accumulated preferentially in the lipids of the spleen and adrenal glands following oral administration.
Absorbed α-tocopherol and its metabolites showed no significant re-entry into the gut lumen via bile or gastric mucosa within 24 hours.
Unchanged α-tocopherol represented the primary radioactive component in liver and spleen lipids, accompanied by tocopherolquinone in both tissues and an additional oxidation product, compound O, in liver lipids.

Cite This Study

Mellors et al. (1966) studied this question.

synapsesocial.com/papers/6a8931ee6ef699e80f1ff5e1 https://doi.org/10.1079/bjn19660009

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Implication

Experimental animal study demonstrates high splenic and adrenal uptake of alpha-tocopherol in rats, indicating tissue retention without rapid gut re-entry.

The distribution and metabolism of α-tocopherol in the rat

Discussion

Member takes

Implication

Key Points

Cite This Study

The distribution and metabolism of α-tocopherol in the rat

Discussion

Member takes

Implication

Key Points

Cite This Study

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