Isothiazol-3(2H)-Ones, Part I: Synthesis, Reactions and Biological Activity

This is the authors' abstract. We don't add key points for this paper.

This review deals with methods for the synthesis, reactions and biological activity of isothiazol-3(2H)-ones. Monocyclic isothiazol-3(2H)-ones have been reported by oxidative cyclization of thiomalonamide derivatives, amides of 3-thionocarboxylic acids and 4,5-dithiaoctanediamides; by cyclocondensation of β-thiosubstituted propenamides and ring contraction of 1,4-thiazepines. Isothiazol-3(2H)-ones and their tautomer OH-forms have been investigated. Isothiazol-3(2H)-ones and their metal salt complexes are potent industrial microbiocides because of antifungal and antibacterial properties.