January 1, 1978The Journal of Clinical Endocrinology & Metabolism

Activation of Human Inactive (“Pro-”) Renin by Cathepsin D and Pepsin*

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Population

Inactive human renin in human amniotic fluid

Comparison

Incubation with cathepsin D at pH 4.8 and 22 C… vs Incubation with pepsin under identical conditions

Design

Preclinical

Follow-up

0-5 hours

Authors

BMBrian J. MorrisNYU Langone Health

Discussion

Member takes

Implication

Supports cathepsin D as a prorenin activator in experimental systems; leaves open its contribution to renin regulation in humans.

Structured PICO

Population

Inactive human renin in human amniotic fluid

Intervention

Incubation with cathepsin D at pH 4.8 and 22 C for 0-5 h

Comparator

Incubation with pepsin under identical conditions

Outcome

Initial velocity of conversion of inactive renin to active reninsurrogate

Cathepsin D is capable of activating inactive human renin, suggesting a potential physiological role in prorenin activation within juxtaglomerular cells.

Cite This Study

Brian J. Morris (1978) studied this question.

synapsesocial.com/papers/6a89326eab4588dbccfb8a8c https://doi.org/10.1210/jcem-46-1-153

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Activation of Human Inactive (“Pro-”) Renin by Cathepsin D and Pepsin*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Activation of Human Inactive (“Pro-”) Renin by Cathepsin D and Pepsin*

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider