Why the study?
Does angiotensin II stimulate prolactin release in rat anterior pituitary cell aggregates?
Does angiotensin II stimulate prolactin release in rat anterior pituitary cell aggregates?
Angiotensin II stimulates prolactin release in rat anterior pituitary cells, suggesting a functional role for the local renin-angiotensin system.
Suggests local RAS modulates prolactin in rat pituitary aggregates; hypothesis-generating, leaves open any human relevance or clinical translation.
Superfusion of rat anterior pituitary cell aggregates with 10-min pulses of 0.1-10 nM angiotensin II (AII) resulted in a prompt and concentration-dependent rise of PRL release. The effect could be blocked by saralasin, an AII receptor antagonist. The response to AII, but not that to TRH, was rapidly desensitized: a 10 nM AII pulse caused an 80% depression of the response to a subsequent 10 nM pulse given 50 min later. The data provide a possible functional significance for the renin-angiotensin system recently demonstrated in the anterior pituitary.
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Schramme et al. (2008) studied this question.
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