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Three human melanomas grown in tissue culture were injected intradermally or subcutaneously into thymus-deficient “nude” mice. Invasive tumors were induced by 2 melanomas at the site of injection. All 3 metastasized to the cervical or inguinal lymph nodes and 1 to the lungs. Karyotypic analysis of the 3 metastatic tumors identified them as human.
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Giovanella et al. (1973) studied this question.
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