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Aculeatins A and B, two naturally occurring bioactive spiroacetals, have been synthesized efficiently in stereoselective manner starting from 1-tetradecanal. The synthetic strategy involves Maruoka enantioselective allylation, diastereoselective iodine-induced electrophilic cyclization, alkylation of a chiral aldehyde and oxidative spirocyclization as the important steps.
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Das et al. (2011) studied this question.
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