facile, environmentally friendly one-pot multicomponent protocol for the synthesis of dihydropyrimidinone (DHPM) and dihydropyrimidin(thio)one (DHPMT) derivatives has been developed using alumina-silica-supported MnO2 as a catalyst in ethanol, demonstrating a green chemistry approach. The Biginelli-type reaction between aryl aldehyde, ethyl acetoacetate, and urea/thiourea afforded DHPM/DHPMT in 85-92% yield within 45 min. Essential features of this protocol include a short reaction time, the use of a heterogeneous catalyst, and convenient catalyst separation.
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Dabas et al. (2026) studied this question.
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