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January 1, 1968The Tohoku Journal of Experimental MedicineOpen Access

Mitosis of Heart Muscle Cells in Normal Rats

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Population

20 normal rats of various ages

Design

Preclinical

Authors

RSRikuro SasakiTohoku UniversityTMToshiaki MorishitaNippon Koei (Japan)SYShoichi YamagataYamagata University

Discussion

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Implication

Urges caution extrapolating rodent data to adult human regeneration; leaves open need for direct human cardiomyocyte studies.

Structured PICO

P
Population
20 normal rats of various ages
I
Intervention
Colchicine administration
O
Outcome
Mitotic rate of heart muscle cells and interstitial cellssurrogate

Heart muscle cells and interstitial cells in rats divide and increase in number with postnatal growth, with mitosis ceasing after 4 weeks for muscle cells.

Cite This Study

Sasaki et al. (1968) studied this question.

synapsesocial.com/papers/6a893447a4df84145ecaf5d3https://doi.org/10.1620/tjem.96.405
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Estimation of the Cell Number of Heart Muscles in Normal Rats1968 · 50 citations
  2. 2THE FINE STRUCTURE OF THE DNP COMPONENT OF THE NUCLEUS1963 · 191 citations
  3. 3Determination of Deoxyribonucleic Acid Content of Heart Muscle and Myocardial Growth in Normal Rats1968 · 16 citations
  4. 4The myocardial lesions of diphtheria1924 · 59 citations