Why the study?
Does the inhibition of PGI2 synthetase enhance the formation of white platelet thrombi in vivo?
Population
In vivo model (arterial wall)
Design
Preclinical
Authors
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Inhibits PGI2 synthetase and enhances platelet thrombi in animals; hypothesis-generating for endothelial nonthrombogenicity, not ready for clinical translation.
Does the inhibition of PGI2 synthetase enhance the formation of white platelet thrombi in vivo?
Inhibition of PGI2 synthetase enhances white platelet thrombus formation, suggesting that PGI2 synthesis is responsible for the nonthrombogenicity of the endothelium.
R.H. Bourgain (2009) studied this question.
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