May 4, 2018Nature CommunicationsOpen Access

Direct neurotransmitter activation of voltage-gated potassium channels

View Full Paper

Ask AI

Bookmark

Population

Voltage-gated potassium channels KCNQ2-5 (specifically KCNQ3 and KCNQ5)

Design

Preclinical

Authors

RMRían W. ManvilleUniversity of California, Irvine MPMaria PapanikolaouHellenic Airforce General Hospital GAGeoffrey W. AbbottElectrophysiology

Discussion

Member takes

Implication

Cannot yet guide clinical decisions on metabolite therapies; leaves open direct KCNQ activation by GABA/BHB in human excitability disorders.

Structured PICO

Population

Voltage-gated potassium channels KCNQ2-5 (specifically KCNQ3 and KCNQ5)

Intervention

Endogenous neurotransmitters including γ-aminobutyric acid (GABA), β-hydroxybutyric acid (BHB), and γ-amino-β-hydroxybutyric acid (GABOB)

Outcome

Direct activation of KCNQ5 and KCNQ3 and shift in voltage dependence of activation

The study reveals a novel paradigm of direct neurotransmitter activation of voltage-gated ion channels, enabling chemosensing to regulate cellular excitability.

Cite This Study

Manville et al. (2018) studied this question.

synapsesocial.com/papers/6a8934c0a90c2f4c44fb8b8b https://doi.org/10.1038/s41467-018-04266-w

View Full Paper

Ask AI

Bookmark

Implication

Cannot yet guide clinical decisions on metabolite therapies; leaves open direct KCNQ activation by GABA/BHB in human excitability disorders.

Direct neurotransmitter activation of voltage-gated potassium channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Direct neurotransmitter activation of voltage-gated potassium channels

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider