April 2, 1994European Heart Journal
Experimental Models of Arrhythmias: Toys or Truth?
Population
Preclinical models: conscious goats and dogs
Design
Preclinical
Follow-up
24 h
Authors
Discussion
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Member takes
Implication
Animal models demonstrate rapid AF-induced remodeling promoting persistence; extends mechanistic insights but leaves open human therapeutic translation.
Structured PICO
P
Population
Preclinical models: conscious goats and dogs
I
Intervention
Artificial maintenance of atrial fibrillation (goats) and local rapid pacing for regional entrainment of induced atrial fibrillation (dogs)
O
Outcome
Electrophysiological changes (atrial refractory period, duration of atrial fibrillation) and termination of atrial fibrillationsurrogate
These experimental models demonstrate that atrial fibrillation induces electrophysiological changes that promote its own maintenance, and that local overdrive pacing is ineffective for termination.
Cite This Study
Allessie et al. (1994) studied this question.