Why the study?
Do different non-depolarizing muscle relaxants and premedication regimens affect QT interval, heart rate, and arterial pressure during anaesthetic induction in patients without cardiovascular disease?
Population
186 patients without cardiovascular diseases or any preoperative drugs undergoing anaesthetic induction
Comparison
Five non-depolarizing muscle relaxants injected… vs Comparisons between the different muscle…
Design
RCT, randomized, double-blind
Follow-up
6.5 minutes
Authors
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QT prolongation during induction is rate-related, not a direct relaxant effect; confirms secondary mechanism in patients without cardiovascular disease.
Do different non-depolarizing muscle relaxants and premedication regimens affect QT interval, heart rate, and arterial pressure during anaesthetic induction in patients without cardiovascular disease?
Prolongation of the QT interval during anesthetic induction with non-depolarizing muscle relaxants appears to be secondary to increases in heart rate rather than a direct drug effect.
Saarnivaara et al. (1988) studied this question.
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