Why the study?
Does vecuronium or atracurium alter the negative chronotropic effect of acetylcholine in the isolated perfused rabbit heart?
Does vecuronium or atracurium alter the negative chronotropic effect of acetylcholine in the isolated perfused rabbit heart?
In an isolated rabbit heart model, atracurium significantly inhibits the negative chronotropic effect of acetylcholine, while vecuronium does not enhance it.
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Vecuronium and atracurium do not enhance acetylcholine bradycardia in rabbit heart; leaves open any clinical relevance to anesthesia.
The bradycardia produced by 1 microgram acetylcholine in the isolated perfused rabbit heart, in the presence of vecuronium and atracurium, was studied and compared with control. Vecuronium at a concentration of 2.5 micrograms/litre and atracurium 6 micrograms/litre did not enhance the negative chronotropic effect of acetylcholine. Atracurium produced a statistically significant inhibition of the negative chronotropic effect of acetylcholine.
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BELLIS et al. (1990) studied this question.
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