Population
Sprague-Dawley rats and spontaneously hypertensive rats (aortas and cerebral microvessels)
Comparison
Nephrectomy and inhibition/removal of… vs Rats not subjected to nephrectomy
Design
Preclinical
Authors
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Challenges prior reports of intrinsic vascular renin; leaves open independent local systems in other models or species.
The study demonstrates that previously reported vascular renin-like activity in rats is likely due to contamination by plasma renin or nonspecific proteases rather than intrinsic tissue renin.
Fordis et al. (1983) studied this question.
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