Palladium‐Catalyzed Intermolecular Ene–Yne Coupling: Development of an Atom‐Efficient Mizoroki–Heck‐Type Reaction

Direct and to the point: A palladium(II) catalytic system based on a palladium hydride species provides access to highly substituted 1,3-dienes through a direct coupling of alkynes with alkenes in a base-free Mizoroki–Heck-type reaction with full atom economy (see scheme; R=amide, borate, C(OH)Me2, Oalkyl).