What question did this study set out to answer?

To outline strategies for maximizing atom economy and minimizing synthetic waste in complex organic synthesis through homogeneous transition metal catalysis.

February 21, 1995Angewandte Chemie International Edition in English

Atom Economy—A Challenge for Organic Synthesis: Homogeneous Catalysis Leads the Way

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To outline strategies for maximizing atom economy and minimizing synthetic waste in complex organic synthesis through homogeneous transition metal catalysis.
Evaluated transition metal complexes capable of steric and electronic tuning via diverse ligand environments.
Surveyed catalytic mechanisms facilitating C–H bond activation, direct additions to π-electron systems, and cycloadditions for carbon–carbon bond generation.
Transition metal catalysts facilitate previously unknown or energetically unfavorable carbon–carbon bond additions under mild reaction conditions.
Preorganization of nonpolar π-electron systems and selective C–H insertions allow construction of molecular skeletons with complete incorporation of reactant atoms.

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Implication

Review demonstrates how transition metal homogeneous catalysis enables atom-economical carbon-carbon bond formation, highlighting pathways to eliminate synthetic waste in complex molecule assembly.

Cite This Study

Barry M. Trost (1995) studied this question.

synapsesocial.com/papers/69dd5dcd4917c2595e101556 https://doi.org/10.1002/anie.199502591

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Implication

Review demonstrates how transition metal homogeneous catalysis enables atom-economical carbon-carbon bond formation, highlighting pathways to eliminate synthetic waste in complex molecule assembly.

Atom Economy—A Challenge for Organic Synthesis: Homogeneous Catalysis Leads the Way

Key Points

Discussion

Implication

Cite This Study

Atom Economy—A Challenge for Organic Synthesis: Homogeneous Catalysis Leads the Way

Key Points

Discussion

Implication

Cite This Study

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