We studied the influence of a commercial cereal-based diet supplemented with bovine blood on Fe, Ca, P, and Mg metabolism in control and Fe-deficient rats to investigate the interactions caused by high levels of dietary Fe and whether heme Fe supplementation could reduce these interactions. After feeding Fe-deficient rats with a diet that contained 100 mg of Fe/kg as elemental Fe, the digestive and metabolic utilization of Ca, P, and Mg decreased, whereas the sternum concentration of these minerals increased in comparison with control rats fed the same diet. Nevertheless, when cereal-based diet was supplemented with heme Fe, no decrease in Ca or Mg absorption was found in Fe-deficient rats.
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Pallarés et al. (1996) studied this question.
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